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Unexplained fertility CAN be treated: Expert digs deeper into the causes

Timed intercourse and ovulation induction with medications will be advised to the couple. Intrauterine insemination (IUI) is used to improve sperm delivery to the egg. In vitro fertilisation (IVF), when other methods fail, can also be suggested.

With careful testing, lifestyle changes, and targeted treatments, many couples still go on to have healthy pregnancies.
With careful testing, lifestyle changes, and targeted treatments, many couples still go on to have healthy pregnancies.
| Updated on: Dec 09, 2025 | 04:22 PM

New Delhi: Unexplained infertility occurs when fertility testing hasn't found a reason for being unable to get pregnant. So, this happens in the case of many couples. It simply means more investigation and a focused, step-by-step plan are needed. With careful testing, lifestyle changes, and targeted treatments, many couples still go on to have healthy pregnancies.

Dr. Rita Modi, Senior IVF Consultant, Motherhood Fertility & IVF, Kharghar, said that unexplained infertility tends to reflect the limitations of standard testing. Routine checks (semen analysis, ovulation confirmation, fallopian tube patency, and basic ovarian reserve tests) can miss subtler problems such as:

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  • Egg quality issues that simple hormone tests don’t reveal.
  • Mild sperm functional problems are not seen on routine semen counts.
  • Subtle fallopian tube dysfunction or tiny adhesions that block egg–sperm meeting.
  • Endometrial receptivity problems: the lining may not be ready for embryo implantation.
  • Immune or inflammatory factors that interfere with fertilisation or implantation.
  • Timing or lifestyle factors (irregular cycles, stress, weight, sleep, smoking, alcohol, or hidden infections).

Hence, it is the need of the hour to dig deeper into these tests

  • Advanced sperm function tests and DNA fragmentation.
  • AMH and antral follicle count to check the ovarian reserve.
  • Tests for uterine lining health and endometrial receptivity will be advised
  • Screening for hidden infections, autoimmune markers, or hormonal imbalances.

Infertility treatment

Timed intercourse and ovulation induction with medications will be advised to the couple. Intrauterine insemination (IUI) is used to improve sperm delivery to the egg. In vitro fertilisation (IVF), when other methods fail, can also be suggested. Personalised medicine involving tailoring stimulation, embryo selection, or endometrial preparation based on deeper tests will be given. So, make sure to maintain an optimum weight, a well-balanced diet, regular exercise, sleep, and quit smoking and alcohol to improve fertility. Stress management through yoga and meditation, and counselling helps couples cope and often improves outcomes. So, consult a specialist who will dig deeper, explain options clearly, and map a hopeful path forward. It is time to follow the instructions given by the expert to improve fertility and conceive successfully.

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