Xenotransplantation is the process of transplanting organs, tissues or cells from one species to another. Most of the ongoing research is focused on transplanting pig organs to humans. Pigs are suitable donors because their organs are similar in size to human organs, and they reproduce quickly, allowing large numbers to be raised. The primary barrier is the human immune system, which recognises the pig tissues as foreign, and attacks them. This results in hyperacute rejection within minutes to hours, triggered by antibodies against pig carbohydrates. Without modifications, xenografts rapidly fail. To overcome rejections, scientists are using gene editing tools such as CRISPR to alter pig DNA. The crucial changes including knocking out certain genes, especially ones associated with producing carbohydrates, to reduce binding by human antibodies. Human genes are added to express proteins, to control coagulation and inflammation. Pigs with 10 or more edits, sometimes up to 69, have...
- Aditya Madanapalle
- Updated on: Jan 29, 2026 | 04:40 PM